A mouse model of short‐term, diet‐induced fatty liver with abnormal cardiolipin remodeling via downregulated Tafazzin gene expression

BACKGROUND Cardiolipin (CL) helps maintain mitochondrial structure and function. Here we investigated whether a high carbohydrate diet (HCD) fed to mice for short period (5 days) could modulate the CL level, including that of monolysoCL (MLCL) in liver. RESULTS Total HCD group was 22% lower than normal chow (NCD) (P < 0.05). The CL72:8 level strikingly decreased by 93% (P < 0.0001), whereas total nascent CLs (CLs other CL72:8) increased (P < 0.01) group. MLCL 2.4-fold compared with NCD Tafazzin expression significantly downregulated A strong positive correlation between (r = 0.955, P < 0.0001), negative (r = -0.593, P = 0.0883) were observed. CONCLUSION modulated fatty acid composition via liver, which lead dysfunction. This model may be useful elucidating relationship liver © 2021 Society Chemical Industry.